high quality bulk organic melatonin

What is organic melatonin,melatonin bulk ? 

Organic melatonin,melatonin bulk is an indolamine that is produced in the pineal gland.organic melatonin,melatonin bulk chemical appellation is N-Acetyl-5-Methoxytryptamine or C13-H16-N2-O2.

How does it effect circadian rhythms ?

Melatonin produces a substances called arginine vasotocin. This secretion has an inhibiting effect upon cortisol, a stress hormone produced by the adrenal glands. Insomniacs typically tend to have high nighttime levels of the hormone which tends to keep them in an agitated state. inhibition of this hormone promotes sleep and allows time for regeneration.

The metabolic pathway by which melatonin is produced, involves a by product of tryptophan called serotonin. When you consider that tryptophan is the least abundant of the essential amino acids in the normal diet, there is a greater likelihood of a melatonin shortfall because the compound it's produced from, serotonin, would also be reduced.

Function:

1 Studies suggest that melatonin supplements may help induce sleep in people with disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift) and those with low melatonin levels (such as some elderly and individuals with schizophrenia). A review of clinical studies suggests that melatonin supplements may help prevent jet lag, particularly in people who cross five or more time zones.

2 A few clinical studies suggest that when taken for short periods of time (days to weeks) melatonin is significantly more effective than a placebo, in decreasing the amount of time required to fall asleep, increasing the number of sleeping hours, and boosting daytime alertness.Best melatonin is manufacturered by Xi'an Rongsheng Biotechnology,choose Rongsheng is your best partner.

3 Multiple human studies have measured the effects of melatonin supplements on sleep in healthy individuals. A wide range of doses has been used, often taken by mouth 30 - 60 minutes prior to sleep time. A study of 334 people aged 55 and older found that prolonged-release melatonin produced significant and clinically meaningful improvements in sleep quality, morning alertness, sleep onset latency, and quality of life in primary insomnia patients aged 55 years and over.

What about cancer ?

Melatonin has been described as being oncastatic. A erm that describes its ability to prevent the proliferation of cancer cells. in studies done by hill and Blask at the university of Arizona School of medicine, melatonin inhibited breast cancer cells by as much as 60 to 70%. In another study done by Lissoni et al., at the San Gerardo Hospital in Milan, Italy, melatonin a significantly improved the survival time of patients with brain metastases when compared to those who were treated with steroids and anticonvulsant agents. It appears that the inhibitory effect melatonin has on cancer cell expansion is directly related to its usage. Drs Hill and blask observed that when the patients stopped using melatonin there was an immediate reversal in their conditions.

What about toxicity ?

Melatonin, which has been studied for the past two decades, has been administered at doses exceeding 200 mg without any adverse effects. The LD 50 tests done on mice were 1375 mg per Kg of body weight which is an enormous amount when applied to humans. Most studies indicate that melatonin is most efficacious when used at a level of between 1 to 3 mg before bedtime. please note, that any substance can prove to be dangerous at some elevated level including oxygen and water. It is therefore prudent to consult with your doctor or health practitioner, when a health concern arises, before supplementing your diet.

Any contradications ?

For those adults, over 40, who aren't pregnant, suffering from an auto-immune or endocrine disorder, using anti-depressant drugs, or have reproductive insufficiencies, melatonin could be quite beneficial when used under the guidance of a doctor.