Coluracetam belongs to the wider group of racetam drugs. It is often touted for its memory boosting properties as well as its positive effects on manic depression and anxiety. Although coluracetam is mainly associated with these benefits, it has also been reported to boost optic properties although ongoing studies are needed to identify the exact mechanisms behind this benefit.
Coluracetam was originally synthesized in Japan by the Mitsubishi Tanabe Pharma Corporation as a potential treatment for Alzheimer’s disease in 2005. When it failed to reach endpoints in its clinical trials it was licensed by BrainCells, Inc for further research.
Memory and Learning
Coluracetam is shown to improve cognitive function and memory in rats, and in theory, the same results are expected in human beings. A study conducted by BrainCells Inc showed a memory improvement in rats who were given substance AF64A (a neuron-specific neurotoxin) for eight days along with coluracetam in 3 mg doses. They were then put through the standardized Morris Water Maze to mark their ability to get through it, and even up to 72 hours after the last 8 mg dose, they were still able to. Another key finding of this study was that the results were still apparent three days after the last dose, even though the serum concentration of coluracetam was negligible.
Depression and Anxiety
BrainCells Inc. found that a dosage of 240 mg (split into three daily doses of 80 mg) was useful in treating major depression with co-morbid GAD (generalized anxiety disorder). However, the differences were most pronounced in those who didn’t find relief in using standard antidepressants. After one dose, there were no noticeable differences, but after two doses of 80 mg, 36% had improved scores during a depression assessment test.
Eyesight
Coluracetam has been associated with optic benefits such as enhanced color vision, recognition, and vividness. Although there isn’t any conclusive evidence to support the mechanisms behind this benefit, experts believe that coluracetam works in the part of the brain that runs visual processes.
Anecdotally, nootropic users report dosing in the range of 3-35 mg up to 3x per day. It is generally advised to begin dosing at the lower side of the ranges to determine your reaction to the substance and work up as desired.
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