A serum that improves skin in multiple ways by acting locally on blemishes and wrinkels. The serum contains epidermal growth factor (EGF) and adiponectin-derived tripeptides, which can improve fine wrinkles and wrinkles around the eyes and glabella. It moisturizes the skin by promoting the production of the skin-barrier component filaggrin, and increases skin elasticity by enhancing collagen production. The serum also reduces skin pigmentations such as the formation of freckles and blemishes, and thus produces a whitening effect.