Backed by 40 years of scientific research, Palmitoylethanolamide (PEA) is one of the most important endogenous painkilling and anti-inflammatory compounds and has been shown to effective for both acute and chronic pain. PEA can help to modulate pain sensitivity by regulating mast cells. Mast cells release bioactive mediators and nerve growth factors which produce inflammation and sensitization of pain-sensing neurons.

5000 Patients in Clinical Trials

To date around 5000 patients have been entered in double blind clinical trials, and the efficacy in chronic pain and inflammation of this natural compound is clearly documented. This makes PEA one of the best documented effective and safe nutraceuticals. There are many hundreds of satisfied US citizens using this natural painkiller. PEA has been used by more than 1 million patients, mostly in Europe. In the Netherlands and Germany since the beginning of 2011 many ten thousands of patients are using it.

Its positive influence in atopic eczema for instance seems to originate from PPAR alpha activation. PEA is available for human use as food for medical purposes. In a 2012 review, all clinical trials to date were summarized. Its positive influence in chronic pain, and inflammatory states such as atopic eczema, seems to originate mainly from PPAR alpha activation.

How to Use Palmitoylethanolamide (PEA) ?

You can start taking three 4 400 mg a day, in 2 or 3 gifts. The dose can be increased up to 2400 mg daily. Mostly we advise patients to double the dose only after 4 weeks, and only in case of issuficient efficaccy.

If pain improves after some weeks to 2 months one might want to decrease dose to 2 times 400 mg.

If no improvement after 2-3 months, stop.

Always inform your physician just to keep him/her in the loop.