Sunifiram, also known as DM-235, is one of the most exciting new developments in nootropics, providing a very powerful cognitive boost along with mood and energy enhancement.
First synthesized in 2000, sunifiram is a very recent discovery and only a limited body of research is available to date, but preliminary animal studies indicate that it’s an effective nootropic proven to improve learning and memory.
First synthesized in 2000, sunifiram is a very recent discovery and only a limited body of research is available to date, but preliminary animal studies indicate that it’s an effective nootropic proven to improve learning and memory.
It is also believed to be a potential treatment for a variety of neurological disorders including Alzheimer’s disease, Parkinson’s disease, and amnesia.
No serious side effects have been identified, though research is ongoing. There have been no documented studies or clinical trials involving humans, but animal studies suggest that sunifiram is both safe and well tolerated and may be even less toxic than racetam nootropics.
Sunifiram is a derivative of the racetam family of nootropics but has a different chemical structure and is classified as a piperazine alkaloid rather than a racetam. It delivers many of the same memory and learning enhancements as piracetam but is as much as 1000 times more potent. Sunifiram is also an ampakine, a compound that interacts with the glutamatergic AMPA receptors to boost the activity of the neurotransmitter glutamine, and as such may deliver significant mood and energy improvement as well as cognitive benefits.
Learning and memory:
Sunifiram has been proven to act as a powerful nootropic, delivering measurable improvements in learning speed, memory retention, and recall. Animal studies showed that sunifiram not only enhanced performance in learning tasks, it actually reversed chemically-induced amnesia.
Improved focus and motivation:
Sunifiram users frequently report that it gives them better focus and concentration and improves their motivation to both tackle and complete mental tasks, and animal studies tend to bear this out. The focus and motivation enhancement effects could be attributable in part to the fact that sunifiram facilitates the release of acetylcholine, the neurotransmitter most closely associated with cognitive ability.
Anxiety and depression management:
Though animal studies don’t suggest that sunifiram acts as an anti-depressant or anxiety reliever, some users report that it has these effects. These effects may be explained at least in part to its actions as an ampakine, or compound that interacts with the glutamatergic AMPA receptors and acts as a mild stimulant.
Mood and energy booster:
Many users report that sunifiram gives them more energy and a brighter, generally happier outlook.
Visual/perceptual enhancement:
While user reports of visual and perceptual improvements are far from universal, many people say that taking sunifiram gives them a brighter outlook in a very literal sense, making light and shadow more pronounced and colors more vibrant. For some people, it also makes music more mentally engaging and emotionally meaningful.
Increased sex drive:
A significant percentage of users report that sunifiram has distinct and noticeable aphrodisiac properties, increasing their interest in sex. This effect doesn’t appear to be universal and has not been replicated in animal studies.
Sunifiram requires a much smaller dose than racetams for effectiveness. Based on a combination of user reports and information gained from animal studies, a dosage of 5 to 10 mg taken a maximum of three times per day is typically considered both safe and effective. Sunifiram is best taken sublingually for maximum absorption.
It is always wise to start with the smallest possible effective dosage of a new supplement and increase gradually as needed, and that advice is particularly pertinent to sunifiram. Not only is it a new drug on which no human trials have been documented, large doses could have unpleasant side effects including over-stimulation and brain fog.
In addition, tolerance to sunifiram may build rapidly. Some users recommend cycling it with other nootropics to avoid this effect.
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